Developmental disorders of the enteric nervous system
نویسندگان
چکیده
منابع مشابه
The enteric nervous system.
T HE enteric nervous system is a collection of neu-rons in the gastrointestinal tract 1 that constitutes the " brain of the gut " and can function independently of the central nervous system. 2 This system controls the motility, 3,4 exocrine and endocrine secretions, 5 and microcirculation 6 of the gastrointestinal tract; it is also involved in regulating immune and inflammatory processes. 7 In...
متن کاملThe human enteric nervous system.
Decades of work in animal models have demonstrated that the enteric nervous system (ENS) plays a key role in controlling gut functions. Recent advances made it possible to extend such studies to the ENS of man in health and even in disease. Such studies have already provided new insights into the pathophysiology of inflammatory and possibly functional bowel diseases. Studies on human ENS reveal...
متن کاملDevelopment of the enteric nervous system.
Development of the ENS requires the function of a diverse set of genes encoding transcription factors, signaling molecules, and their receptors. Mutations of these genes result in altered ENS function in animals and humans. In particular, such mutations have been shown to contribute to many cases of Hirschsprung's disease. Elucidation of the mechanisms of ENS development and function allow the ...
متن کاملDevelopment of the zebrafish enteric nervous system.
The enteric nervous system (ENS) is composed of neurons and glia that modulate many aspects of intestinal function. The ability to use both forward and reverse genetic approaches and to visualize development in living embryos and larvae has made zebrafish an attractive model in which to study mechanisms underlying ENS development. In this chapter, we review the recent work describing the develo...
متن کاملGaseous Mediators in the Enteric Nervous System
The enteric nervous system is an independent nervous system that controls vital gut functions including motility and secretion. Enteric neurons use a variety of neurotransmitters to modulate neural as well as muscle and epithelial activity. Among them are three gaseous mediators which are nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H2S). All three have potent inhibitory effec...
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ژورنال
عنوان ژورنال: Gut
سال: 2000
ISSN: 0017-5749
DOI: 10.1136/gut.47.suppl_4.iv81